Mechanisms of dexamethasone-induced bone toxicity in developing bone: a single-cell perspective.

However, there may be significant differences in the mechanisms, severity, and duration of dexamethasone’s effects between children and adults, as pediatric patients have developing bones characterized by high turnover rates and ongoing remodeling. 6 , 18 In developing bones, bone growth relies on chondrocyte proliferation and differentiation, followed by endochondral ossification in the epiphyseal plates.

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Moreover, TRAP activity in the tibia metaphysis showed a decreasing trend with dexamethasone treatment, although this was not statistically significant.

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We found that the bone volume fraction (BV/TV) was significantly reduced, and trabecular thickness showed a trend toward a decrease in DEX 50 mice compared to the vehicle-treated group ( Figure 1E-G ).

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