Single-nucleus transcriptomics reveals sepsis-related neurovascular dysfunction in the human hippocampus.

GSEA analysis revealed that both Microglia 1 ( Figure 2C ) and Microglia 2 ( Figure 2D ) exhibited enrichment trends in hallmark inflammatory pathways, including TNF-α/NF-κB signaling ( 29 ), IL6–JAK–STAT3 signaling ( 30 ), and inflammatory response, although these did not reach statistical significance.

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