National Eye Institute Supported Randomized Controlled Trials in Keratoplasty for Endothelial Disorders: Lessons Learned.

Although the ABO-compatible group experienced fewer overall graft failures, rejection-related failures, and rejection episodes, these differences did not reach statistical significance. 24 The CCTS also evaluated other risk factors for graft failure and rejection. 29 Key risk factors identified included younger recipient age, multiple previous grafts, prior anterior segment surgeries, preoperative glaucoma, extensive anterior synechiae, stromal vascularization, chemical burns as the primary diagnosis, and ABO blood group incompatibility.

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