Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression.

For the SN, there was a stronger interaction ( b = −0.03, SE = 0.01, t [89.6] = −3.47, p < 0.001) due to a borderline significant increase in contrast with age in HC ( b = 0.04, SE = 0.02, t [26] = 1.93, p = 0.06) and a significant decrease in AD ( b = −0.03, SE = 0.01, t [69.9] = −3.17, p = 0.002).

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The relationship between LC contrast and bilateral gray matter ( b = 1.50, SE = 0.80, t [19] = 1.87, p = 0.08), left gray matter ( b = 1.46, SE = 0.83, t [19] = 1.77, p = 0.09), and right gray matter ( b = 1.54, SE = 0.84, t [19] = 1.83, p = 0.08) JD showed a trend level relationship, that is, a trend to faster volume loss with lower contrast (Figure 7A,D ).

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