Scaffolds with spatiotemporally controlled growth factor delivery and cyclodextrin-enabled antagonism of growth factor receptor sequestration promote cutaneous wound healing.

To this end, previous studies have shown a correlation between healing outcome and systemic statin use by patients with chronic wounds, albeit this trend did not reach statistical significance ( p = 0.057 ) 101 , while around the same time a different group demonstrated that statin use was independently associated with a 52% risk reduction of lower-extremity amputation 102 .

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