Development of a leucine-rich repeat-containing protein 15-targeted radio-immunotheranostic approach to deplete pro-tumorigenic mechanisms and immunotherapy resistance.

Comparison of LRRC15/Lrrc15 expression in cancer cells and stroma of HuO9 and U118MG tumors across clusters showed a trend of decreased expression with increasing cluster distance from untreated samples in both cancer cells and stroma (Fig. 6d ); the expression of TGFB1 , a known regulator of LRRC15 expression, mirrored the LRRC15/Lrrc15 expression pattern (Fig. 6d ).

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