Interleukin-27-adipose-derived mesenchymal stromal cell-based gene therapy attenuates inflammation in lipopolysaccharide-induced acute respiratory distress syndrome.

Although the ASC group exhibited some histological improvement, the lung injury score did not reach statistical significance.

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There was also an increasing trend in TNF-α and NFĸB expression as LPS dose increased; however, there was a slight reduction in gene expression observed at the 1500 ng/mL dose, possibly due to toxicity at high LPS concentrations, as seen in previous studies [ 38 ].

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The total protein concentration in the BALF also aligned with these results, showing a decreasing trend in protein levels in both ASC groups (with and without IL-27).

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