Pde5a deficiency prevents diet-induced obesity via adipose cAMP-PKA activation enhancing fat browning.

Basal oxygen consumption rate (OCR), a measure of mitochondrial aerobic respiration, and extracellular acidification rate (ECAR), an indicator of lactate production [ 26 ], showed a trend toward higher values in adipocytes derived from Pde5a −/− mice compared to WT controls ( Figure 2 H and S1J ).

also in 53,322 other papers