SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma.

Cancer Immunol Res · 2025 · PMC12485372 · PMID 40680256

Europe PMC DOI

hedged sentences

0.0680

closest p · 1.4× alpha

0.5790

boldest claim

The sentences

marginally significantP = 0.068so close (0.05 < p ≤ 0.1)

Furthermore, attenuated effector (IFNγ: P = 0.017; TNFα: P = 0.068; marginally significant) and cytotoxic functions (GZMB: P = 0.020) were observed in CD8 + T cells with high SPP1 + TAM infiltration, indicating impaired antitumor activity ( Fig. 3J and K ; Supplementary Fig.

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did not reach statistical significanceP = 0.579not close (p > 0.1)

1K ), although PFS did not reach statistical significance in either of the two arms ( P = 0.579 and P = 0.958; Supplementary Fig.

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