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Beta cells to brain cells: The pivotal role of insulin and glucose metabolism in Alzheimer's disease.

Neuroprotection · 2025 · PMC12486931 · PMID 41383947

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Some studies have been encouraging though failed to reach statistical significance for certain populations or due to device failure. 168 , 169 , 170 , 171 The paradox of beneficial effects versus problematic hyperinsulinemia and glycemic variability may explain at least some of the contrary outcomes.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.