Epigenetic drift score captures directional methylation variability and links aging to transcriptional, metabolic, and genetic alterations.

Genome Res · 2025 · PMC12487821 · PMID 40750330

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nominally significantP < 2.2 × 10 −16actually significant

Our results indicated that 48.1% ( n = 11,422, P < 0.05) of the examined drift-CpGs exhibited a nominally significant difference (OR = 5.0, Fisher's test, P < 2.2 × 10 −16 ) between these two time points.

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