Disentangling associations between complex traits and cell types with seismic.

To further complement the power simulation and examine robustness to false positives, we also quantified the frequency that the non-perturbed cell types (cell types without simulated trait-specific signals) reach a nominally significant statistical significance. seismic still maintained well-controlled false positive ratios consistent with the expected theoretical threshold (Supplementary Fig. 7 ) across multiple traits whose GWAS exhibit diverse sample sizes and genetic architectures.

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