A comparison of these meta-programs between paired samples from the same patients revealed that downregulation of NF-κB signaling (meta-program 2) was associated with tumor relapse following ASCT or R-chemotherapy, whereas the MYC-targeted program (meta-program 3) consistently showed a trend of downregulation after ASCT ( Figure 2 D).
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Tumor evolution and immune microenvironment dynamics in primary and relapsed mantle cell lymphoma.
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