Deep brain stimulation improves symptoms across all dimensions in treatment-resistant depression.

Neurotherapeutics · 2025 · PMC12491800 · PMID 40500658

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did not reach statistical significanceno p-value reported

Symptom severity at pre-operative baseline in the affective/anhedonia dimension tended to correlate with DBS response although this did not reach statistical significance (F (1,32) = 3.80, p = 0.06), and symptom severity at pre-operative baseline in the insomnia dimension was not significantly correlated with DBS response (F (1,32) = 0.006, p = 0.94).

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