Barely Significant
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Global burden of chronic kidney disease due to diabetes mellitus type 2 attributable to low physical activity and high body mass index from 1990 to 2021.

Biol Sport · 2025 · PMC12492348 · PMID 41048221

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showed a trendno p-value reported
For birth cohort effects, DALYs rate for CKD-T2DM attributable these two modifiable behavioral risk factors generally showed a trend similar to that of period effects ( Figure 3D and 3H ).

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a decreasing trendno p-value reported
Globally, the ASR of deaths and DALYs for CKD-T2DM attributable to low PA maintains a relatively stable trend since 1990, while the proportion of CKD-T2DM burden due to low PA show a decreasing trend.

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an increasing trendno p-value reported
With respect to temporal patterns, the low-PA-related CKD-T2DM burden in high SDI region presents an increasing trend in past 3 decades, however, jointpoint analysis revealed a decreasing trend with a segmental AAPC of -0.63% during 2015 and 2021.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.