Impact of Neoadjuvant Chemotherapy on Surgical Outcomes and Conversion to Node-Negativity in Invasive Lobular Breast Cancer: Analysis of Molecularly High-Risk Tumors by Histologic Subtype on the I-SPY2 Clinical Trial.

Ann Surg Oncol · 2025 · PMC12494636 · PMID 40705266

Europe PMC DOI

hedged sentence

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

did not reach statistical significancep = 0.058so close (0.05 < p ≤ 0.1)

When mastectomy was performed as the initial surgery, the difference in positive margin rates by histologic subtype did not reach statistical significance (7.8% in lobular cases vs. 2.4% in non-lobular cases; p = 0.058) [Table 2 ].

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