Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screening.

Nat Commun · 2025 · PMC12501029 · PMID 41053170

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showed a trendno p-value reported

2 and 4 ) as well as E3 ligase binders ( 16 and 17 ) showed a trend towards more effective GSK3β degradation.

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