Nonmuscle myosin 2 turnover in cells is synergistically controlled by the tail and the motor domain.

Proc Natl Acad Sci U S A · 2025 · PMC12501154 · PMID 40996796

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a nonsignificant trendno p-value reported

However, a nonsignificant trend toward greater values in the case of NM2BA relative to NM2A might reflect a marginal effect of the NM2A motor domain, the idea supported by the experiments shown below.

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showed a trendno p-value reported

Importantly, the NM2BA-ΔNHT/2SA mutant showed a trend of increasing rather than decreasing the histogram width, suggesting that it could be even less dynamic than wild type NM2B.

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