Antihypertensive Drugs and Dental Caries Risk: A Drug-Target Mendelian Randomization Analysis.

For example, the protective effect of CCBs on dental caries risk in the FinnGen cohort remained highly significant in the MR‐PRESSO analysis (OR: 0.9709; 95% CI: 0.9503–0.9837; p = 2.23 × 10 −4 ) reinforcing the validity of our primary findings. 3.3.

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Any drug class that did not show a nominally significant protective effect on CAD risk ( p < 0.05) was excluded from further analysis, as this would suggest that the genetic instruments were not validly proxying the drug′s antihypertensive action. 2.4.2.

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