MicroRNA gene dynamics in immune cell subpopulations during aging and atherosclerosis disease development at single-cell resolution.

Genome Med · 2025 · PMC12502174 · PMID 41053866

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The disease-associated increase in LAM reflects as target gene enrichment signature for mmu-miR-23b and mmu-miR-27b (mmu-miR-24–1 nominally significant) that match the same pri-miRNA locus, while both tissue monocytes and LAM expression could contribute to mmu-miR-221 ~ 222 target enrichment (Figs. 3 and 4 ).

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