HPV associated oropharyngeal cancer in eastern China over the last 7 years: is the incidence in chinese truly exceptionally low?

Similarly, when examining the yearly occurrence of OPSCC in males, we found a significant trend for both p16 positive cases (Spearman r = 0.9286, p = 0.0067; linear regression R 2 = 0.8675, p = 0.0023) and p16 negative cases (Spearman r = 0.8469, p = 0.0238; linear regression R 2 = 0.7591, p = 0.01) (Fig. 1 C).

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Furthermore, we also observed an increasing trend towards a higher prevalence of p16-positive cases among females, consistent with previous findings from studies conducted in the United States and Italy [ 21 , 28 ].

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