A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison.

When GS was left out, 11 out of the 15 tested CpG sites remained nominally significant ( P < 8.91 × 10 −3 ).

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There was an increasing trend of effect sizes as the P -value threshold for MS calculation became increasingly stringent (Fig. 3 ).

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