Specialized pro-resolving mediators alleviate inflammation and cartilage breakdown in vitro and may play a pivotal role in platelet-rich plasma.

Sci Rep · 2025 · PMC12504750 · PMID 41057538

Europe PMC DOI

hedged sentence

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

showed a trendp = 0.054so close (0.05 < p ≤ 0.1)

PRP/SPM-high treatment also significantly reduced the gene expression of MMP13 ( p = 0.034) and showed a trend toward lower COL2A1 expression ( p = 0.054) compared to PRP/SPM-low.

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