Alternative Polyadenylation Contributes to Fibroblast Senescence in Pulmonary Fibrosis.

The levels of Cleavage and Polyadenylation Specific Factor 6 (CPSF6) and CPSF7—cofactors of NUDT21 within the cleavage factor Im (CFIm) complex—also showed a trend toward downregulation in aged and IPF lungs, though these changes were less consistent than those observed for NUDT21 (Figure 1A ).

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