Efficacy of different allergen-specific immunotherapies for the treatment of allergic rhinitis in children and adults: an umbrella review.

Front Immunol · 2025 · PMC12507858 · PMID 41080605

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did not reach statistical significancep = 3.17e-10actually significant

Although the majority of the findings in these included studies did not reach statistical significance, the overall efficacy assessment indicated that SLIT demonstrated effectiveness in pediatric AR patients (SS: SMD=-0.52, 95%CI=-0.75~-0.29, p = 3.17e-10, I2=0%, Egger’s test: p = 0.74; MS: SMD=-0.24, 95%CI=-0.37~-0.11, p = 0.0356, I2=78.68%, Egger’s test: p = 0.34) ( Figure 6 ).

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