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Insights into the adoption of innovative clinical trials across therapeutic areas using clinical trials registry data and large Language models.

Sci Rep · 2025 · PMC12508068 · PMID 41062537

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an increasing trendno p-value reported
The distribution of trials over time shows an increasing trend in innovative trials, particularly from 2011 onwards, with these trials being more frequently active, suspended, terminated, or withdrawn than traditional trials (Table S2).

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The overall effect of adopting an innovative design, compared to a traditional design, adjusted for the therapeutic area, did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.