The global, regional, and national burden of acute lymphoblastic leukemia, 1990 to 2021: a cross-sectional analysis from the 2021 global burden of disease study.

Discov Oncol · 2025 · PMC12508354 · PMID 41060501

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a clear trendno p-value reported

Frontier analysis There is a clear trend between ASDR values and SDI across different countries/regions.

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a decreasing trendno p-value reported

In low SDI regions, despite a decreasing trend (EAPC: − 0.89; 95% CI: − 0.96 to − 0.82), the absolute number of prevalent cases increased from 9,329.8 in 1990 (95% UI: 5,355.7–15,542.2) to 15,460.6 in 2021 (95% UI: 9,593.3–19,874.1), likely due to population growth and improved case detection (Table 1 ; Fig. 1 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.