The Janus Face of SPAG6: Inducing EMT in Luminal Breast Cancer Cells Amidst Widespread Expression Loss in Breast Tumours.

However, we observed an interesting trend in our dataset suggesting that SPAG6 may act as an oncogene in luminal A tumours.

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Currently, our hypothesis that luminal breast tumours with a TP53 mutation and high SPAG6 expression may represent a more aggressive subtype can only be considered a noteworthy point for future SPAG6 expression studies, since the TP53 status was not available for the PlanB cohort and the potential SPAG6‐induced oncogenic phenotype in the PlanB breast cancer cohort (HR 1.64, p = 0.085) did not reach statistical significance.

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