A high-calorie diet exacerbates lipopolysaccharide-induced pneumonia by promoting acetate-mediated macrophage polarization via the HDAC9/10-HIF-1α-glycolysis axis.

Front Immunol · 2025 · PMC12510825 · PMID 41080555

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did not reach statistical significanceno p-value reported

We found that a high-calorie diet significantly increased the proportion of M1-like (CD206 − CD86 + ) macrophages in lung tissue ( P < 0.05), while showing a trend toward reducing the proportion of M2-like (CD206 + CD86 − ) macrophages, though this did not reach statistical significance.

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