Pharmacokinetic-pharmacodynamic target attainment analyses as support for meropenem dosing regimens in critically ill adult and elderly patients with <i>Pseudomonas aeruginosa</i> infections.

A notable trend of decreasing CrCL was observed as the age of patients increased, which consequently led to a reduction in the CL of meropenem.

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As illustrated in Figure 2 , the age-normalized Vd increased with advancing age, indicating a clear trend across different age groups. 3.4 Model validation The robustness and stability of the final pharmacokinetic model were evaluated using both bootstrapping ( Table 2 ) and prediction-corrected visual predictive checks ( Figure 3 ).

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