Differential Expression of One-Carbon Pathway Enzyme ALDH1L1 Is Linked to Tumorigenicity of Low-Grade Bladder Cancer Cells Through Metabolic Reprogramming.

Cancer Med · 2025 · PMC12512356 · PMID 41070972

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moderately significantno p-value reported

Using a cut‐off of −log 10 ( p ‐value) = 1.3 for pathway enrichment significance, the RT4 versus sh506 comparison is characterized by strong differences in pyrimidine metabolism, as well as in alanine, aspartate, and glutamate metabolism, with moderately significant differences in pantothenate biosynthesis, beta‐alanine metabolism, and glutathione metabolism.

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