Relevance of a peripheral site of action outside the brain-blood barrier for the beneficial effects of CB<sub>2</sub> receptor activation in experimental ALS in male mice.

In contrast, the central agonist only showed a trend toward significance for Iba-1 ( p = 0.07) (Fig. 4 A) and a lower level of significance for CD68 ( p < 0.05) (Fig. 4 C), although, looking at the single values, it was evident that some animals showed a complete reversion in glial activation, but this occurred in groups having a very large variability.

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Anyway, the effects produced by RO-6871304 did not reach statistical significance at any of the timepoints recorded during the treatment (see Fig. 7 ).

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