Dissecting regulatory non-coding GWAS loci reveals fibroblast causal genes with pathophysiological relevance to heart failure.

Nat Commun · 2025 · PMC12514315 · PMID 41073375

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hedged sentence

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closest p · 0.0× alpha

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nominally significantP = 1.0E-04actually significant

rs35346340 is a significant FURIN eQTL in esophageal mucosa ( P = 2.0E-13) and a nominally significant eQTL of this gene in aortic artery ( P = 1.0E-04), and FURIN is highly expressed in both primary and immortalized cardiac fibroblasts.

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