Synthetic inhibition of the SUMO pathway by targeting the SAE1 component via TAK-981 compound impairs growth and chemosensitizes embryonal and alveolar rhabdomyosarcoma cell lines.

Mol Cell Biochem · 2025 · PMC12515125 · PMID 40549307

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showed a trendno p-value reported

SUMO2/3 (p = 0.005), SAE1 (p = 0.036), SENP1 (p = 0.04), SENP3 (p = 0.001), and SENP5 (p = 0.002) were upregulated, PIAS1 (p = 0.004) was downregulated; UBA2 (p = 0.51) showed a trend of downregulation in both tumor samples and RMS cell lines.

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