Opposing Synovial Cannabinoid Receptor Type 2 and Transient Receptor Potential Vanilloid 1 Expression in Painful Osteoarthritis.

When comparing the means between the KOOS pain quartiles, the difference in CGRP levels were nearly significant, with higher mean concentration in the high-pain group (low pain: 24.7 ± 16.2 pg/mL versus high pain: 40.7 ± 23.5 pg/mL; p = 0.0547) (Figure 2E ). 2-AG and AEA levels in SF LC-MS/MS analysis of endocannabinoids in SF revealed significantly higher levels of 2-AG in patients in the high-pain group (20.9 ± 10.3 ng/mL) compared to the low-pain group (14.9 ± 7.1 ng/mL) (p = 0.0358) (Figure 3A ).

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