Germline determinants of toxicity and efficacy in patients with large B-cell lymphoma treated with CAR T-cell therapy.

J Immunother Cancer · 2025 · PMC12516986 · PMID 41067879

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reached borderline significanceno p-value reported

In the analysis of genetic susceptibility to CRS of any grade, the distribution of PRS for monocyte count (p=0.063), white blood cell count (p=0.081), interleukin (IL)-6RA levels (p=0.080), and IL-8 levels (p=0.099) reached borderline significance in those who experienced CRS as compared with those who did not.

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