Bidirectional causality between liver dysfunction and migraine: A mediating Mendelian randomization study.

Medicine (Baltimore) · 2025 · PMC12517790 · PMID 41088633

Europe PMC DOI

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0.2600

closest p · 5.2× alpha

0.2600

boldest claim

The sentences

did not reach statistical significanceP = .26not close (p > 0.1)

Specifically, using 5 screened SNPs significantly associated with migraine as instrumental variables for IVW analysis, the results showed that the causal effect of migraine on bilirubin levels did not reach statistical significance (OR = 0.97, 95% CI: 0.90–1.02, P = .26).

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