Mutation of conserved MHC class I cytoplasmic tyrosine affects CD8+ T cell priming, effector function, and memory response.

Both transferred OT-I and endogenous OVA-specific T cells showed a trend of more robust expansion in the Y320E-SCT group following the secondary antigen encounter, with endogenous OVA-specific T cells expanding significantly faster in the Y320E-SCT group ( Figure 4B ).

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