Dephosphorylation of astrocyte elevated gene-1 protein upregulates eIF4E expression to promote gastric cancer progression.

PPP1R21 expression was significantly higher in gastric cancer tissues than in normal tissues and tended to increase disease progression, as we observed higher expression levels in late-stage cancers (stages III and IV) than in early-stage cancers (stages Ib and IIa), although this difference did not reach statistical significance ( Fig. 7 , G and H ).

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