In addition, mRNA levels of PIM3 were higher in osteosarcoma tissues compared with corresponding normal tissues ( Supplemental Figure 9G ), and high PIM3 mRNA levels trended toward lower overall survival, although this association did not reach statistical significance ( Supplemental Figure 9H ).
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PIM3-mediated phosphorylation stabilizes myeloid leukemia factor 2 to promote metastasis in osteosarcoma.
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