Amyloid-β-driven Alzheimer's disease reshapes the colonic immune system in mice.

Consistently, an increasing trend in the frequency of IgA + cells was observed in blood; however, no differences were observed in the spleen, where the overall IgA frequencies were very low ( Figure S10C ).

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We also observed a near-significant increase in class-switched B220SP B2 cells in the brain, along with a decrease in naive B cells ( Figure 3H ).

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