Severe COVID-19 induces prolonged elevation of the acute-phase protein pentraxin 3.

GSEM analysis revealed a significant positive effect of the homozygous wt (A/A) genotype on PTX-3 serum levels (standardized path coefficient of β = 0.259, p = 0.0300) and a highly significant effect of PTX-3 serum levels on disease severity (β = 0.468, (p < 0.0010; Figure 5B ).

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While most severe COVID-19 patients showed a trend toward normalization of PTX-3 levels at 10 months post-infection, a substantial subset still presented with serum concentrations exceeding 5000 pg/ml ( Figure 3 ).

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