MDA-MB-231 breast cancer cells adapted to anchorage-independent growth reveal senescent-like phenotype and persistent downregulation of PD-L1 expression.

Conversely, ATIC and IMPDH1 , other important enzymes in this pathway, showed a decreasing trend ( Supplementary Figure S29 ).

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In contrast, CCND1 (Cyclin D1) a key regulator of cell cycle progression, exhibited a slight trend of upregulation in CLONE Met+2DG (ns), as well as its binding kinase CDK6 ( Supplementary Figures S12D, F ).

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STUB1 , which promotes the ubiquitination and degradation of p65 (subunit of NF-κB), showed a trend of downregulation in CLONE 2DG , CLONE Met+2DG and CLONE polyHEMA (all ns) ( Supplementary Figure S9B ).

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We indeed observed an increasing trend in the percentage detached cells in CLONE 2DG compared WT 2DG cells treated with 4.8 2DG, however the increase was not statically significant ( Figure 2B ).

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