Identification of novel amino acid variants in the Han Chinese population that impair toll-like receptor 4 signaling and confer hyporesponsiveness to lipopolysaccharide.

Densitometry analysis revealed that TLR4 expression in the SAP model groups (TLR4 wild-type and p.(Arg804Trp) variant) was only marginally higher than in the normal saline control group, although this difference did not reach statistical significance ( Figure 5K ).

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