GnRH agonist pretreatment in hormonal endometrial preparation: a comparison of two protocols for frozen embryo transfer outcomes.

Front Med (Lausanne) · 2025 · PMC12521422 · PMID 41103701

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did not reach statistical significanceno p-value reported

GnRHa–HRT displayed a trend of increasing the live birth rate (OR = 2.125, 95%CI:0.948–4.762, p = 0.067), but the difference did not reach statistical significance.

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a decreasing trendno p-value reported

In the PCOS–endometriosis (EMs) subgroup, the spontaneous abortion rate had a decreasing trend, but the difference was not statistically significant ( p > 0.05).

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an increasing trendno p-value reported

The positive rate of β -HCG, clinical pregnancy rate, implantation rate, and live birth rate showed an increasing trend in the GnRHa–HRT group, and the GnRHa–HRT group showed a decrease in spontaneous abortions.

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borderline significantno p-value reported

This “borderline significant” result may also be limited by the single-center nature of the study, insufficient sample size, or confounding factors that were not fully controlled for (e.g., individual patient differences, details of the ovulation regimen).

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