Combined effect of metformin and ezetimibe on PPAR-γ and adiponectin gene expression and biochemical parameters in MAFLD patients with type 2 diabetes.

In the Met + EZY group, the observed upregulation of PPAR-γ gene expression at both three months and six months remained highly significant after FDR correction (adjusted p < 0.001).

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The current study demonstrated that while fasting blood sugar (FBS), 2-hour postprandial plasma glucose (2HPP), and HbA1c levels decreased after six months of treatment with Metformin (Met) and Metformin-Ezetimibe (Met + EZY), these reductions did not reach statistical significance.

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