Lomitapide response in a cohort of patients with homozygous familial hypercholesterolemia and the potential influence of MTTP gene variants.

Orphanet J Rare Dis · 2025 · PMC12522312 · PMID 41088305

Europe PMC DOI

hedged sentence

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

approached significancep = 0.08so close (0.05 < p ≤ 0.1)

There was a mean of 16 variants per patient with LDL-C reduction > 50%, compared with a mean of 8 variants per patient with LDL-C reduction ≤ 50%, and this difference approached significance (difference, 8.5; 95% CI − 1.2, 18.1; p = 0.08; Table 4 ).

also in 8,237 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.