Cyclin-dependent kinase 4/6 inhibitors beyond progression in hormone receptor-positive, HER2-negative advanced breast cancer: a systematic review and meta-analysis (REIGNITE study).

Although statistical significance was lost with its exclusion, the effect size showed a trend consistent with the primary analysis ( Supplementary Figure S3 , available at https://doi.org/10.1016/j.esmoop.2025.105808 ).

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