Genome-wide association study reveals genetic mechanisms underlie eye disorders and comorbidities.

HGG Adv · 2026 · PMC12524058 · PMID 40974049

Europe PMC DOI

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closest p · 0.0× alpha

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boldest claim

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nearly significantp = 1.02 × 10 −7actually significant

For AMD, we identified one genome-wide significant locus in 18q22.2, rs12956753 (OR = 1.71, p = 3.76 × 10 −8 ), and another nearly significant locus in 15q14, rs138597498 (OR = 1.75, p = 1.02 × 10 −7 ), located near the genes DOK6 and DPH6 , respectively ( Figure 1 B).

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