A Targeted Blockade of Terminal C5a Is Critical to Management of Sepsis and Acute Respiratory Distress Syndrome: The Mechanism of Action of Vilobelimab.

Int J Mol Sci · 2025 · PMC12524425 · PMID 41096893

Europe PMC DOI

hedged sentence

0.0940

closest p · 1.9× alpha

0.0940

boldest claim

The sentences

did not reach statistical significancep = 0.094so close (0.05 < p ≤ 0.1)

The site-stratified analysis, recommended by the FDA for the Phase 3 study, showed the same reduction in absolute mortality but did not reach statistical significance (HR 0.73, 95% CI 0.50–1.06; p = 0.094).

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